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Plenary & Workshop Speakers
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Brief Biography of Professor Ava Kwong Professor Ava Kwong presently holds the position of the Chief of the Breast Surgery Division, In 2009, she founded the Women’s Surgical Chapter at the College of Surgeons of Hong Kong Aside from her clinical and academic positions, she contributes to the governmental bodies and In 2007, she founded the Hong Kong Hereditary Breast Cancer Family Registry, where she In 2013, she was elected to be the Deputy Chief and Committee Member of the Shenzhen During her surgical career, she has gained multiple awards and scholarships, including the Her main research interests include breast and ovarian cancer genetics, advanced surgical She has authored various chapters in medical books including “ABC of Breast Disease” Aside from her academic, clinical and author work she is also very supportive of patients Her contributions in the academic, community and charity work has won herself community |
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Hereditary breast cancer and management options for genetic mutation carrier Mutations due to hereditary related genes such as BRCA1, BRCA2, TP53, PTEN and PALB2 confer greater risk of developing breast cancer and for BRCA mutations, and where relevant, also ovarian cancer. The risk assessment based on genetic testing allows options of high risk surveillance, prevention and may now also guide use of specific therapies for treatment such as targeted therapies and use of platinum base chemotherapy. Prophylactic surgery (bilateral mastectomy, bilateral salpingo-oophorectomy or a combination of both procedures) has proved to be the most effective risk-reducing strategy for breast cancer and ovarian cancer but there are no randomised controlled trials able to demonstrate the potential benefits or harms of prophylactic surgery and most of the evidence has been derived from retrospective and short follow-up prospective studies, in addition to hypothetical mathematical models. Based on the current knowledge, it is reasonable to recommend prophylactic oophorectomy for BRCA1 or BRCA2 mutation carriers when childbearing is completed in order to reduce the risk of developing breast and ovarian cancer. In addition, women should be offered the options of intensive breast surveillance, chemoprevention or bilateral prophylactic mastectomy. The selection of the most appropriate risk-reducing strategy however is not simple. The impact of risk-reducing strategies on cancer risk, survival, and overall quality of life are the key criteria considered for decision-making. Various other factors should be taken into consideration when evaluating individual mutation carriers’ individual situation, namely woman’s age, morbidity, type of mutation, and individual preferences and expectations. Various strategies, existing guidelines and surgical options will be reviewed and discussed. |
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